Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 2014

Eigler Tamar, Ben-Shlomo Anat, Zhou Cuiqi, Khalafi Ramtin, Ren Song-Guang, Melmed Shlomo

Abstract excerpt

Somatostatin signals through somatostatin receptor subtypes (SSTR) 2 and 5 to attenuate GH secretion. Although expressed in normal pituitary glands and in GH-secreting pituitary tumors, SSTR3 function was unclear, and we have now determined the role of SSTR3 in somatotroph function. Stable rat pituitary tumor cell (GC) transfectants of human SSTR3 (GpSSTR3(WT)) showed suppression of rat (r) GH promoter activity,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Growth Hormone

Share to HEK293 Cells

Share to Receptors, Somatostatin

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 24606125
DOI: 10.1210/me.2013-1327
PMCID: PMC3968402

Genes

SSTR3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.PMID 24606125Read ↗

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11.Semantic proximity Read ↗

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue ReceptorsSemantic proximity Read ↗

Molecular Analysis of Rat Pituitary and Hypothalamic Growth Hormone Secretagogue ReceptorsSemantic proximity Read ↗

Natriuretic Peptide Expression and Function in GH3 Somatolactotropes and Feline Somatotrope Pituitary Tumours.Semantic proximity Read ↗

Truncated somatostatin receptors as new players in somatostatin–cortistatin pathophysiologySemantic proximity Read ↗

Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.Semantic proximity Read ↗

A Dominant-Negative Human Growth Hormone-Releasing Hormone (GHRH) Receptor Splice Variant Inhibits GHRH BindingSemantic proximity Read ↗

Filamin A (FLNA) Plays an Essential Role in Somatostatin Receptor 2 (SST2) Signaling and Stabilization After Agonist Stimulation in Human and Rat Somatotroph Tumor CellsSemantic proximity Read ↗

Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.Semantic proximity Read ↗

Genomic Structure and Transcriptional Regulation of the Human Growth Hormone Secretagogue Receptor<sup>1</sup>Semantic proximity Read ↗

Metabolic insights from a GHSR-A203E mutant mouse model.Semantic proximity Read ↗

Somatostatin receptor subtype 2 and 5 in human GH-secreting pituitary adenomas: analysis of gene sequence and mRNA expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.