Article
Increased N7-methyldeoxyguanosine DNA adducts after occupational exposure to pesticides and influence of genetic polymorphisms of paraoxonase-1 and glutathione S-transferase M1 and T1.
Environmental and molecular mutagenesis - 1 Jun 2015
Gómez-Martín Antonio, Altakroni Bashar, Lozano-Paniagua David, Margison Geoffrey P, de Vocht Frank, Povey Andrew C, Hernández Antonio F
Abstract excerpt
There are concerns about genetic risks associated with long-term exposure to pesticides as these compounds may damage DNA, resulting in mutations that eventually lead to cancer, neurological, and reproductive adverse health effects. This study assessed DNA damage in intensive agricultural workers exposed to pesticides by determining the levels of N7-methyldeoxyguanosine (N7-MedG), an adduct known to be a robust...
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