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Article

On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2006

Roses Allen D

Abstract excerpt

The association of Apolipoprotein E-4 with the age of onset of common late-onset Alzheimer's disease (AD) was originally reported in three 1993 papers from the Duke ADRC (Alzheimer's Disease Research Center) group. The Center was investigating two diverse experimental streams that led to this discovery. The first being a genetic linkage study performed in multiplex familial late-onset AD in which a linkage was...

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Identifiers

PMID: 16914873
DOI: 10.3233/jad-2006-9s340

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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