Article
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-gamma 1 phosphorylation on tyrosine residues 783 and 1254.
Cell - 3 May 1991
Kim H K, Kim J W, Zilberstein A, Margolis B, Kim J G, Schlessinger J, Rhee S G
Abstract excerpt
PDGF binding to its receptor promotes the association with and stimulates the phosphorylation of PLC-gamma 1 at tyrosine and serine residues. Also, PDGF induces an increase in the hydrolysis of inositol phospholipids by PLC. How PDGF activates PLC was investigated by substituting phenylalanine fo...
Topics
- Animals
- Base Sequence
- Cell Line
- Hydrolysis
- Isoenzymes
- Molecular Sequence Data
- Mutation
- Peptides
- Phosphatidylinositol 4,5-Diphosphate
- Phosphatidylinositols
- Phosphorylation
- Phosphotyrosine
- Platelet-Derived Growth Factor
- Receptors, Cell Surface
- Receptors, Platelet-Derived Growth Factor
- Serine
- Transfection
- Type C Phospholipases