Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication efficiency of chimeric replicon containing NS5A-5B genes derived from HCV-infected patient sera.

Antiviral research - 1 Jan 2007

Tripathi Rakesh L, Krishnan Preethi, He Yupeng, Middleton Tim, Pilot-Matias Tami, Chen Chih-Ming, Lau Daryl T Y, Lemon Stanley M, Mo Hongmei, Kati Warren, Molla Akhteruzzaman

Abstract excerpt

A transient subgenomic replicon-based shuttle vector system has been developed to investigate how genetic heterogeneity affects HCV replication efficiency. Individual NS5A or NS5B genes or cassettes containing both NS5A and NS5B genes were amplified from "quasispecies" pools derived from HCV genotype 1a or 1b patient sera using RT-PCR and cloned into their respective shuttle vectors. All shuttle vectors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C

Share to Recombinant Fusion Proteins

Share to Replicon

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Identifiers

PMID: 16914212
DOI: 10.1016/j.antiviral.2006.07.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication efficiency of chimeric replicon containing NS5A-5B genes derived from HCV-infected patient sera.PMID 16914212Read ↗

A replicon-based shuttle vector system for assessing the phenotype of HCV NS5B polymerase genes isolated from patient populations.Semantic proximity Read ↗

Replication-competent chimeric hepatitis C virus subgenomic replicons.Semantic proximity Read ↗

Hepatitis C virus genotype 5a subgenomic replicons for evaluation of direct-acting antiviral agents.Semantic proximity Read ↗

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.Semantic proximity Read ↗

Replication studies using genotype 1a subgenomic hepatitis C virus replicons.Semantic proximity Read ↗

Development of robust genotype 1a hepatitis C replicons harboring adaptive mutations for facilitating the antiviral drug discovery and study of virus replication.Semantic proximity Read ↗

Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a.Semantic proximity Read ↗

Robust and persistent replication of the genotype 6a hepatitis C virus replicon in cell culture.Semantic proximity Read ↗

Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.Semantic proximity Read ↗

In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.Semantic proximity Read ↗

Development of a chimeric replicon system for phenotypic analysis of NS3 protease sequences from HCV clinical isolates.Semantic proximity Read ↗

Evolution of naturally occurring 5' non-translated region variants of hepatitis C virus genotype 1b in selectable replicons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.