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Article

Evolution of naturally occurring 5' non-translated region variants of hepatitis C virus genotype 1b in selectable replicons.

The Journal of general virology - 1 Jul 2004

van Leeuwen Hans C, Reusken Chantal B E M, Roeten Marko, Dalebout Tim J, Riezu-Boj Jose Ignacio, Ruiz Juan, Spaan Willy J M

Abstract excerpt

Quasispecies shifts are essential for the development of persistent hepatitis C virus (HCV) infection. Naturally occurring sequence variations in the 5' non-translated region (NTR) of the virus could lead to changes in protein expression levels, reflecting selective forces on the virus. The extreme 5' end of the virus' genome, containing signals essential for replication, is followed by an internal ribosomal...

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PMID: 15218170
DOI: 10.1099/vir.0.79924-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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