Article
eIF5A binds to translational machinery components and affects translation in yeast.
Biochemical and biophysical research communications - 6 Oct 2006
Zanelli Cleslei F, Maragno Ana L C, Gregio Ana P B, Komili Suzanne, Pandolfi José R, Mestriner Carlos A, Lustri Wilton R, Valentini Sandro R
Abstract excerpt
The putative translation factor eIF5A is essential for cell viability and is highly conserved from archebacteria to mammals. Although this protein was originally identified as a translation initiation factor, subsequent experiments did not support a role for eIF5A in general translation. In this work, we demonstrate that eIF-5A interacts with structural components of the 80S ribosome, as well as with the...
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