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Article

An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.

The EMBO journal - 4 Oct 2006

Singh Chingakham Ranjit, Lee Bumjun, Udagawa Tsuyoshi, Mohammad-Qureshi Sarah S, Yamamoto Yasufumi, Pavitt Graham D, Asano Katsura

Abstract excerpt

In eukaryotic translation initiation, the eIF2.GTP/Met-tRNA(i)(Met) ternary complex (TC) binds the eIF3/eIF1/eIF5 complex to form the multifactor complex (MFC), whereas eIF2.GDP binds the pentameric factor eIF2B for guanine nucleotide exchange. eIF5 and the eIF2Bvarepsilon catalytic subunit possess a conserved eIF2-binding site. Nearly half of cellular eIF2 forms a complex with eIF5 lacking Met-tRNA(i)(Met), and...

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Identifiers

PMID: 16990799
DOI: 10.1038/sj.emboj.7601339
PMCID: PMC1589998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation.PMID 16990799Read ↗

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Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.Semantic proximity Read ↗

Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2Semantic proximity Read ↗

Interactions of eukaryotic translation initiation factor 3 (eIF3) subunit NIP1/c with eIF1 and eIF5 promote preinitiation complex assembly and regulate start codon selection.Semantic proximity Read ↗

eIF5A binds to translational machinery components and affects translation in yeast.Semantic proximity Read ↗

eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.Semantic proximity Read ↗

Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2.Semantic proximity Read ↗

Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.Semantic proximity Read ↗

eIF2β is critical for eIF5-mediated GDP-dissociation inhibitor activity and translational control.Semantic proximity Read ↗

eIF2A, an initiator tRNA carrier refractory to eIF2α kinases, functions synergistically with eIF5B.Semantic proximity Read ↗

Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation.Semantic proximity Read ↗

The beta/Gcd7 subunit of eukaryotic translation initiation factor 2B (eIF2B), a guanine nucleotide exchange factor, is crucial for binding eIF2 in vivo.Semantic proximity Read ↗

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