Article
Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae.
PloS one - 9 Feb 2010
Clarkson Bryan K, Gilbert Wendy V, Doudna Jennifer A
Abstract excerpt
Initiation factor eIF4G is a key regulator of eukaryotic protein synthesis, recognizing proteins bound at both ends of an mRNA to help recruit messages to the small (40S) ribosomal subunit. Notably, the genomes of a wide variety of eukaryotes encode multiple distinct variants of eIF4G. We found that deletion of eIF4G1, but not eIF4G2, impairs growth and global translation initiation rates in budding yeast under...
Topics
- Base Sequence
- Cell Division
- Eukaryotic Initiation Factor-4F
- Eukaryotic Initiation Factor-4G
- Gene Expression Profiling
- Gene Expression Regulation, Fungal
- Molecular Sequence Data
- Mutation
- Oligonucleotide Array Sequence Analysis
- Polyribosomes