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Article

Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.

The Journal of biological chemistry - 2 Mar 2001

Das S, Ghosh R, Maitra U

Abstract excerpt

Eukaryotic translation initiation factor 5 (eIF5) forms a complex with eIF2 by interacting with the beta subunit of eIF2. This interaction is essential for eIF5-promoted hydrolysis of GTP bound to the 40 S initiation complex. In this work, we show that, in addition to the eIF2 beta-binding region at the C terminus of eIF5, the N-terminal region of eIF5 is also required for eIF5-dependent GTP hydrolysis. Like...

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Identifiers

PMID: 11092890
DOI: 10.1074/jbc.M008863200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein.PMID 11092890Read ↗

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