Article
Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases.
Breast cancer research and treatment - 1 Apr 2007
Torres Lurdes, Ribeiro Franclim R, Pandis Nikos, Andersen Johan A, Heim Sverre, Teixeira Manuel R
Abstract excerpt
Conflicting theories of epithelial carcinogenesis disagree on the clonal composition of primary tumors and on the time at which metastases occur. In order to study the spatial distribution of disparate clonal populations within breast carcinomas and the extent of the genetic relationship between primary tumors and regional metastases, we have analyzed by comparative genomic hybridization 122 tissue samples from...
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