Article
Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas.
The Journal of pathology - 1 Apr 2010
Geyer Felipe C, Weigelt Britta, Natrajan Rachael, Lambros Maryou B K, de Biase Dario, Vatcheva Radost, Savage Kay, Mackay Alan, Ashworth Alan, Reis-Filho Jorge S
Abstract excerpt
Cancers may be composed of multiple populations of submodal clones sharing the same initiating genetic lesions, followed by the acquisition of divergent genetic hits. Intra-tumour genetic heterogeneity has profound implications for cancer clinical management. To determine the extent of intra-tumo...
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