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Article

Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression.

The Journal of biological chemistry - 13 Oct 2006

Xiao Zhousheng, Zhang Shiqin, Mahlios Josh, Zhou Gan, Magenheimer Brenda S, Guo Dayong, Dallas Sarah L, Maser Robin, Calvet James P, Bonewald Lynda, Quarles Leigh Darryl

Abstract excerpt

We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a transmembrane protein that is a component of the polycystin-2 (PC2)-ciliary mechano-sensor complex in renal epithelial cells. We found that MC3T3-E1 osteoblasts and MLO-Y4 osteocytes express transcripts for PC1, PC2, and the ciliary proteins Tg737 and Kif3a. Immunohistochemical analysis detected cilia-like structures in MC3T3-E1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16905538
DOI: 10.1074/jbc.M604772200
PMCID: PMC1797154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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