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Article

Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.

The Journal of biological chemistry - 1 Aug 2014

Lin Shuxian, Zhang Qi, Cao Zhengguo, Lu Yongbo, Zhang Hua, Yan Kevin, Liu Ying, McKee Marc D, Qin Chunlin, Chen Zhi, Feng Jian Q

Abstract excerpt

Dentin matrix protein 1 (DMP1) plays multiple roles in bone, tooth, phosphate homeostasis, kidney, salivary gland, reproductive cycles, and the development of cancer. In vitro studies have indicated two different biological mechanisms: 1) as a matrix protein, DMP1 interacts with αvβ3 integrin and activates MAP kinase signaling; and 2) DMP1 serves as a transcription co-factor. In vivo studies have demonstrated its...

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Identifiers

PMID: 24917674
DOI: 10.1074/jbc.M113.543330
PMCID: PMC4118114

Genes

DMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.PMID 24917674Read ↗

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Dentin Matrix Protein 1, a Target Molecule for Cbfa1 in Bone, Is a Unique Bone Marker GeneSemantic proximity Read ↗

Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype.Semantic proximity Read ↗

The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development.Semantic proximity Read ↗

Long-term clinical outcome and carrier phenotype in autosomal recessive hypophosphatemia caused by a novel DMP1 mutation.Semantic proximity Read ↗

Dentin matrix protein 1 regulates dentin sialophosphoprotein gene transcription during early odontoblast differentiation.Semantic proximity Read ↗

Dentin sialophosphoprotein and dentin matrix protein-1: Two highly phosphorylated proteins in mineralized tissues.Semantic proximity Read ↗

Studies of the DMP1 57-kDa Functional Domain both in vivo and in vitroSemantic proximity Read ↗

Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets.Semantic proximity Read ↗

A Mutation in the Dmp1 Gene Alters Phosphate Responsiveness in Mice.Semantic proximity Read ↗

DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis.Semantic proximity Read ↗

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