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Article

Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2006

Cox Michael C, Low Jennifer, Lee James, Walshe Janice, Denduluri Neelima, Berman Arlene, Permenter Matthew G, Petros William P, Price Douglas K, Figg William D, Sparreboom Alex, Swain Sandra M

Abstract excerpt

PURPOSE: The herbal supplement garlic (Allium sativum) is commonly used by cancer patients. Preclinical studies have shown that allicin, a major component of garlic, may affect cytochrome P450 3A4 (CYP3A4) activity. This study examines the influence of garlic supplementation on the pharmacokinetics of docetaxel, a CYP3A4 substrate. EXPERIMENTAL DESIGN: Women with metastatic breast cancer were treated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16899612
DOI: 10.1158/1078-0432.CCR-06-0388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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