Article
Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2007
Tham Lai-San, Holford Nicholas H G, Hor Sok-Ying, Tan Theresa, Wang Lingzhi, Lim Rui-Chen, Lee How-Sung, Lee Soo-Chin, Goh Boon-Cher
Abstract excerpt
PURPOSE: This study aims to describe a population pharmacokinetic model for docetaxel in Asian breast cancer patients and to evaluate the effects of single-nucleotide polymorphisms (SNP) in the cytochrome P450 3A (CYP3A) gene expression regulators, constitutive androstane receptor (CAR), pregnane X receptor (PXR), and hepatic nuclear factor 4alpha (HNF4alpha), on the pharmacokinetics of docetaxel. EXPERIMENTAL...
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