Article
The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.
Cancer chemotherapy and pharmacology - 1 Jun 2011
Chew Sin-Chi, Singh Onkar, Chen Xiangai, Ramasamy Rathi Devi, Kulkarni Tejal, Lee Edmund J D, Tan Eng-Huat, Lim Wan-Teck, Chowbay Balram
Abstract excerpt
PURPOSE: This exploratory study aimed to explain the interindividual variabilities of docetaxel pharmacokinetics and pharmacodynamics in Asian nasopharyngeal carcinoma patients (n = 54) through the genotyping of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 genes. METHODS: Docetaxel was administered over 1 h on days 1, 8, and 15 every 28 days at 30 mg/m(2)/dose. Genomic DNA was isolated from peripheral blood...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.