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Article

Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2012

de Graan Anne-Joy M, Lancaster Cynthia S, Obaidat Amanda, Hagenbuch Bruno, Elens Laure, Friberg Lena E, de Bruijn Peter, Hu Shuiying, Gibson Alice A, Bruun Gitte H, Corydon Thomas J, Mikkelsen Torben S, Walker Aisha L, Du Guoqing, Loos Walter J, van Schaik Ron H N, Baker Sharyn D, Mathijssen Ron H J, Sparreboom Alex

Abstract excerpt

PURPOSE: Docetaxel is extensively metabolized by CYP3A4 in the liver but mechanisms by which the drug is taken up into hepatocytes remain poorly understood. We hypothesized that (i) liver uptake of docetaxel is mediated by the polymorphic solute carriers OATP1B1 and OATP1B3 and (ii) inherited genetic defects in this process may impair systemic drug elimination. EXPERIMENTAL DESIGN: Transport of docetaxel was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22711709
DOI: 10.1158/1078-0432.CCR-12-0761
PMCID: PMC3464009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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