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Article

Explaining interindividual variability of docetaxel pharmacokinetics and pharmacodynamics in Asians through phenotyping and genotyping strategies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Sept 2002

Goh Boon-Cher, Lee Soo-Chin, Wang Ling-Zhi, Fan Lu, Guo Jia-Yi, Lamba Jatinder, Schuetz Erin, Lim Robert, Lim Hong-Liang, Ong Ai-Bee, Lee How-Sung

Abstract excerpt

PURPOSE: To explain the variability of docetaxel pharmacokinetics through study of CYP3A phenotype and genotype, and MDR1 genotype. PATIENTS AND METHODS: We studied the pharmacokinetics and pharmacodynamics of docetaxel in patients in whom it was indicated and who had not received known CYP3A4 substrates. Midazolam was administered intravenously to these patients at least 2 days before docetaxel treatment, and...

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Share to Antineoplastic Agents, Phytogenic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oxidoreductases, N-Demethylating

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Source

Identifiers

PMID: 12202670
DOI: 10.1200/JCO.2002.01.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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