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Article

Pharmacogenetic screening of CYP3A and ABCB1 in relation to population pharmacokinetics of docetaxel.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2006

Bosch Tessa M, Huitema Alwin D R, Doodeman Valerie D, Jansen Robert, Witteveen Els, Smit Wim M, Jansen Rob L, van Herpen Carla M, Soesan Marcel, Beijnen Jos H, Schellens Jan H M

Abstract excerpt

PURPOSE: Despite the extensive clinical experience with docetaxel, unpredictable interindividual variability in efficacy and toxicity remain important limitations associated with the use of this anticancer drug. Large interindividual pharmacokinetic variability has been associated with variation...

Read the complete abstract on PubMed

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Share to Antineoplastic Agents, Phytogenic
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Cytochrome P-450 CYP3A

Share to Docetaxel

Share to Metabolic Clearance Rate

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Source

Identifiers

PMID: 17020985
DOI: 10.1158/1078-0432.CCR-05-2649

Genes

ABCB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17020985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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