Article
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
The Journal of clinical investigation - 1 Nov 2007
van Herwaarden Antonius E, Wagenaar Els, van der Kruijssen Cornelia M M, van Waterschoot Robert A B, Smit Johan W, Song Ji-Ying, van der Valk Martin A, van Tellingen Olaf, van der Hoorn José W A, Rosing Hilde, Beijnen Jos H, Schinkel Alfred H
Abstract excerpt
Cytochrome P450 3A (CYP3A) enzymes constitute an important detoxification system that contributes to primary metabolism of more than half of all prescribed medications. To investigate the physiological and pharmacological roles of CYP3A, we generated Cyp3a-knockout (Cyp3a-/-) mice lacking all functional Cyp3a genes. Cyp3a-/- mice were viable, fertile, and without marked physiological abnormalities. However, these...
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