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Article

Pharmacogenetic impact of docetaxel on neoadjuvant treatment of breast cancer patients.

Pharmacogenomics - 1 Nov 2018

Sim Sarah, Bergh Jonas, Hellström Mats, Hatschek Thomas, Xie Hanjing

Abstract excerpt

AIM: This study aimed to investigate the effect of CYP3A4 and CYP3A5 genotypes on clinical outcomes of docetaxel treatment. PATIENTS & METHODS: In the PROMIX trial, 150 breast cancer patients received docetaxel preoperatively. CYP3A4 and CYP3A5 genotype combinations were transformed into total CYP 3A phenotypes. RESULTS: Seven patients were characterized as poor metabolizer (PM), 22 patients as extensive...

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Source

Identifiers

PMID: 30196760
DOI: 10.2217/pgs-2018-0080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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