Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features.

Histopathology - 1 Feb 2005

Pauls K, Merkelbach-Bruse S, Thal D, Büttner R, Wardelmann E

Abstract excerpt

AIMS: To study the immunohistochemical and histological features of 158 gastrointestinal stromal tumours (GISTs), consisting of 137 tumours with mutations in c-kit and platelet-derived growth factor receptor-alpha (PDGFRalpha) genes and 21 wt-GISTs. Additionally, we evaluated the localization of PDGFRalpha in the normal intestine. PDGFRalpha gene mutations were recently described in a subset of GISTs and it has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Blotting, Western
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Gastrointestinal Stromal Tumors

Share to Immunohistochemistry

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 15693889
DOI: 10.1111/j.1365-2559.2005.02061.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PDGFRalpha- and c-kit-mutated gastrointestinal stromal tumours (GISTs) are characterized by distinctive histological and immunohistochemical features.PMID 15693889Read ↗

Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations.Semantic proximity Read ↗

[Gastrointestinal stromal tumors carrying PDGFRalpha mutations occur preferentially in the stomach and exhibit an epithelioid or mixed phenotype].Semantic proximity Read ↗

Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.Semantic proximity Read ↗

Gastrointestinal stromal tumors--definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis.Semantic proximity Read ↗

Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics.Semantic proximity Read ↗

Pathology of Gastrointestinal Stromal TumorsSemantic proximity Read ↗

PDGFRalpha gene mutation and protein expression in gastrointestinal stromal tumors.Semantic proximity Read ↗

An overview on molecular biology of KIT/PDGFRA wild type (WT) gastrointestinal stromal tumours (GIST)Semantic proximity Read ↗

Gastrointestinal Stromal TumorsSemantic proximity Read ↗

Differential expression of KIT/PDGFRA mutant isoforms in epithelioid and mixed variants of gastrointestinal stromal tumors depends predominantly on the tumor site.Semantic proximity Read ↗

Gastrointestinal stromal tumours – an update for histopathologistsSemantic proximity Read ↗

Pathology and diagnostic criteria of gastrointestinal stromal tumors (GISTs): a review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.