Article
[Status and clinical analysis of c-kit and PDGFRA mutations in the gastrointestinal stromal tumors].
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery - 1 Jul 2008
Du Chun-Yan, Shi Ying-Qiang, Zhou Ye, Fu Hong, Zhao Guang-Fa
Abstract excerpt
OBJECTIVE: To investigate the status of c-kit and PDGFRA mutations in the gastrointestinal stromal tumors (GIST) and explore the relationship between the mutations and the clinical features. METHODS: One hundred and forty-one cases were evaluated for the presence of c-kit and PDGFRA mutations. Exon 9,11,13, 17 of c-kit and exon 12, 18 of PDGFRA were analyzed by PCR amplification and direct sequencing. The...
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