Article
Increased expression of the G gamma and A gamma globin genes associated with a mutation in the A gamma enhancer.
Blood - 15 Jun 1994
Balta G, Brickner H E, Takegawa S, Kazazian H H, Papayannopoulou T, Forget B G, Atweh G F
Abstract excerpt
We have previously described a unique type of delta beta-thalassemia in a Chinese family characterized by increased expression of the G gamma and A gamma fetal globin genes in the absence of a large deletion in the beta-globlin gene cluster. Our earlier study of the beta-globin gene on this delta beta-thalassemia chromosome showed a promoter mutation in the TATA box. In this report, we describe the results of our...
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