Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional profile of the human fetal gamma-globin gene upstream promoter region.

American journal of human genetics - 1 Aug 1992

Lin H J, Han C Y, Nienhuis A W

Abstract excerpt

We performed a systematic functional analysis of the human gamma-globin promoter to identify its activator domains. We used a panel of truncation and scanning mutants as well as transfection in human K562 fetal erythroid cells. The various mutations produced relatively small changes in promoter function in both transient and stable transfection assays. The CACCC region and the region containing the binding sites...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to DNA
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 1642236
PMCID: PMC1682667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional profile of the human fetal gamma-globin gene upstream promoter region.PMID 1642236Read ↗

The upstream region of the human gamma-globin gene promoter. Identification and functional analysis of nuclear protein binding sites.Semantic proximity Read ↗

Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.Semantic proximity Read ↗

A T-to-G transversion at nucleotide -567 upstream of HBG2 in a GATA-1 binding motif is associated with elevated hemoglobin F.Semantic proximity Read ↗

Comparative studies of nondeletional HPFH gamma-globin gene promoters.Semantic proximity Read ↗

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity.Semantic proximity Read ↗

Characterization of the -16C>G sequence variation in the promoters of both HBG1 and HBG2: convergent evolution of the human gamma-globin genes.Semantic proximity Read ↗

Increased expression of the G gamma and A gamma globin genes associated with a mutation in the A gamma enhancer.Semantic proximity Read ↗

Functional and sequence analysis of human neuroglobin gene promoter regionSemantic proximity Read ↗

Developmentally specific role of the CCAAT box in regulation of human gamma-globin gene expression.Semantic proximity Read ↗

Transcriptional potential of the gamma-globin gene is dependent on the CACCC box in a developmental stage-specific manner.Semantic proximity Read ↗

Analysis of functional elements in the human Egr-1 gene promoterSemantic proximity Read ↗

Transient expression assay of Agamma-588 (A/G) mutations in the K562 cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.