Article
Functional profile of the human fetal gamma-globin gene upstream promoter region.
American journal of human genetics - 1 Aug 1992
Lin H J, Han C Y, Nienhuis A W
Abstract excerpt
We performed a systematic functional analysis of the human gamma-globin promoter to identify its activator domains. We used a panel of truncation and scanning mutants as well as transfection in human K562 fetal erythroid cells. The various mutations produced relatively small changes in promoter f...
Topics
- Base Sequence
- Chloramphenicol O-Acetyltransferase
- DNA
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Genetic Vectors
- Globins
- Humans
- Leukemia, Erythroblastic, Acute
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- Transcription Factors
- Transfection
- Tumor Cells, Cultured
- Zinc Fingers