Article
Transient expression assay of Agamma-588 (A/G) mutations in the K562 cell line.
Iranian biomedical journal - 1 Jan 2011
Hamid Mohammad, Mahjoubi Frouzandeh, Akbari Mohammad Taghi, Khanahmad Hossein, Jamshidi Fatemeh, Zeinali Sirous, Karimipoor Morteza
Abstract excerpt
BACKGROUND: In the previous study, we have shown that the presence of A allele at position -588 in Agamma-globin gene was highly frequent and closely associated with fetal hemoglobin elevation among beta-thalassemia intermedia patients. Therefore, we decided to investigate whether this allele (A allele at -588) could result in an increase in Agamma-globin gene expression to ameliorate the severity of the disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.