Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.

Experimental biology and medicine (Maywood, N.J.) - 1 Mar 2006

Navas Patrick A, Li Qiliang, Peterson Kenneth R, Stamatoyannopoulos George

Abstract excerpt

A silencing element has been previously located upstream of the human epsilon-globin gene promoter using transient assays and transgenic mice carrying plasmid constructs in which the element has been deleted or its transcriptional motifs have been mutated. To investigate whether this element functions in the context of the whole beta-globin locus, we analyzed epsilon-globin gene expression in transgenic mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Yeast
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Embryo, Mammalian

Share to Erythropoiesis

Share to Gene Deletion

Share to Gene Expression Regulation, Developmental

Share to Gene Silencing

Share to Globins

Source

Open in PubMed Open full text

Identifiers

PMID: 16514181
DOI: 10.1177/153537020623100314
PMCID: PMC2812921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigations of a human embryonic globin gene silencing element using YAC transgenic mice.PMID 16514181Read ↗

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice.Semantic proximity Read ↗

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Semantic proximity Read ↗

Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.Semantic proximity Read ↗

Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus.Semantic proximity Read ↗

Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.Semantic proximity Read ↗

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity.Semantic proximity Read ↗

An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domainSemantic proximity Read ↗

Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.Semantic proximity Read ↗

Development of virus vectors for gene therapy of β chain hemoglobinopathies: flanking with a chromatin insulator reduces γ-globin gene silencing in vivoSemantic proximity Read ↗

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.Semantic proximity Read ↗

Studies on DNA—protein interactions in the upstream regulatory region of the human #epsilon#—globin gene promoterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.