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Article

Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker.

The Journal of general physiology - 1 Feb 2000

Gonzalez C, Rosenman E, Bezanilla F, Alvarez O, Latorre R

Abstract excerpt

In Shaker K(+) channels depolarization displaces outwardly the positively charged residues of the S4 segment. The amount of this displacement is unknown, but large movements of the S4 segment should be constrained by the length and flexibility of the S3-S4 linker. To investigate the role of the S3-S4 linker in the ShakerH4Delta(6-46) (ShakerDelta) K(+) channel activation, we constructed S3-S4 linker deletion...

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Identifiers

PMID: 10653896
DOI: 10.1085/jgp.115.2.193
PMCID: PMC2217197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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