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Article

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

The Journal of biological chemistry - 7 Jan 2011

Choveau Frank S, Rodriguez Nicolas, Abderemane Ali Fayal, Labro Alain J, Rose Thierry, Dahimène Shehrazade, Boudin Hélène, Le Hénaff Carole, Escande Denis, Snyders Dirk J, Charpentier Flavien, Mérot Jean, Baró Isabelle, Loussouarn Gildas

Abstract excerpt

Voltage-dependent potassium (Kv) channels are tetramers of six transmembrane domain (S1-S6) proteins. Crystallographic data demonstrate that the tetrameric pore (S5-S6) is surrounded by four voltage sensor domains (S1-S4). One key question remains: how do voltage sensors (S4) regulate pore gating...

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Identifiers

PMID: 20940310
DOI: 10.1074/jbc.M110.146324
PMCID: PMC3013029

Genes

KCNQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20940310-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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