Article
Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats.
Molecular carcinogenesis - 1 Dec 2001
Suzui M, Sugie S, Mori H, Okuno M, Tanaka T, Moriwaki H
Abstract excerpt
Mutations in the region corresponding to the N-terminal phosphorylation sites (codons 1-51) of the rat beta-catenin gene (Ctnnb1) were investigated in rat colon tumors induced by 1-hydroxyanthraquinone (1-HA) plus methylazoxymethanol (MAM) acetate, by using polymerase chain reaction (PCR)-single-strand conformation polymorphism (SSCP) analysis. The beta-catenin gene was also screened for mutations in rat brain...
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