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Article

Feedback-resistant mutations in Bacillus subtilis glutamine synthetase are clustered in the active site.

Journal of bacteriology - 1 Aug 2006

Fisher Susan H, Wray Lewis V

Abstract excerpt

The feedback-inhibited form of Bacillus subtilis glutamine synthetase regulates the activity of the TnrA transcription factor through a protein-protein interaction that prevents TnrA from binding to DNA. Five mutants containing feedback-resistant glutamine synthetases (E65G, S66P, M68I, H195Y, and P318S) were isolated by screening for colonies capable of cross-feeding Gln(-) cells. In vitro enzymatic assays...

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Source

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Identifiers

PMID: 16885465
DOI: 10.1128/JB.00544-06
PMCID: PMC1540052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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