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Article

Aptamer redesigned tRNA is nonfunctional and degraded in cells.

RNA (New York, N.Y.) - 1 Jan 2004

Lee Dennis, McClain William H

Abstract excerpt

An RNA aptamer derived from tRNA(Gln) isolated in vitro and a rationally redesigned tRNA(Gln) were used to address the relationship between structure and function of tRNA(Gln) aminoacylation in Escherichia coli. Two mutant tRNA(Gln) sequences were studied: an aptamer that binds 26-fold tighter to glutaminyl-tRNA synthetase than wild-type tRNA(Gln) in vitro, redesigned in the variable loop, and a mutant with...

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Source

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Identifiers

PMID: 14681579
DOI: 10.1261/rna.5165804
PMCID: PMC1370512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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