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Article

Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence.

Infection and immunity - 1 Feb 1997

Klose K E, Mekalanos J J

Abstract excerpt

In Salmonella typhimurium, transcription of the glnA gene (encoding glutamine synthetase) is under the control of the nitrogen-regulatory (ntr) system comprising the alternate sigma factor sigma54 (NtrA) and the two-component sensor-transcriptional activator pair NtrB and NtrC. The glnA, ntrB, and ntrC genes form an operon. We measured the virulence of S. typhimurium strains with nitrogen-regulatory mutations...

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Identifiers

PMID: 9009317
DOI: 10.1128/iai.65.2.587-596.1997
PMCID: PMC176100

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Source receipt: pubmed, retrieved 7 Sept 2026.

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