Article
Simultaneous prevention of glutamine synthesis and high-affinity transport attenuates Salmonella typhimurium virulence.
Infection and immunity - 1 Feb 1997
Klose K E, Mekalanos J J
Abstract excerpt
In Salmonella typhimurium, transcription of the glnA gene (encoding glutamine synthetase) is under the control of the nitrogen-regulatory (ntr) system comprising the alternate sigma factor sigma54 (NtrA) and the two-component sensor-transcriptional activator pair NtrB and NtrC. The glnA, ntrB, an...
Topics
- Animals
- Base Sequence
- Biological Transport
- Female
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Glutamine
- Macrophages
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Nitrogen
- Operon
- Salmonella typhimurium
- Transcription, Genetic
- Virulence