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Article

Metabolic engineering for L-glutamine overproduction by using DNA gyrase mutations in Escherichia coli.

Applied and environmental microbiology - 1 May 2013

Hayashi Mikiro, Tabata Kazuhiko

Abstract excerpt

An L-glutamine-overproducing mutant of an Escherichia coli K-12-derived strain was selected from randomly mutagenized cells in the course of L-alanyl-L-glutamine strain development. Genome-wide mutation analysis unveiled a novel mechanism for L-glutamine overproduction in this mutant. Three mutations were identified that are related to the L-glutamine overproduction phenotype, namely, an intergenic mutation in...

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Identifiers

PMID: 23455340
DOI: 10.1128/AEM.03994-12
PMCID: PMC3623149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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