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Article

SPARC Represses E-Cadherin and Induces Mesenchymal Transition during Melanoma Development

1 Aug 2006

Abstract excerpt

During progression of melanoma, loss of the cell-cell adhesion molecule E-cadherin contributes to uncontrolled growth and invasive behavior of transformed melanocytes. Secreted protein acidic and rich in cysteine (SPARC) is a nonstructural matricellular protein that regulates cell-matrix interactions leading to alterations in cell adhesion and proliferation. Overexpression of SPARC has been associated with...

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PMID: 16885349
DOI: 10.1158/0008-5472.can-05-3189

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SPARC Represses E-Cadherin and Induces Mesenchymal Transition during Melanoma DevelopmentPMID 16885349Read ↗

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