Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Emerging role of ARHGAP29 in melanoma cell phenotype switching.

Molecular oncology - 1 Feb 2026

Tröster Beatrice Charlotte, Kappelmann-Fenzl Melanie, Bosserhoff Anja Katrin, Rachinger Nicole

Abstract excerpt

Rho GTPase-activating protein 29 (ARHGAP29) is an inhibitor of the Ras homolog family member A (RhoA)/Rho-associated protein kinase (ROCK) signaling pathway. Studies in non-melanoma cancer entities described that ARHGAP29 modulates the actin cytoskeleton, promoting tumor cell invasion. In melanoma, its function has been completely unknown. Our transcriptomic analyses revealed a strong expression of ARHGAP29 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cell Movement
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTPase-Activating Proteins

Share to Melanoma

Share to rho-Associated Kinases

Share to rhoA GTP-Binding Protein

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 40906537
DOI: 10.1002/1878-0261.70114
PMCID: PMC12936434

Genes

ARHGAP29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Emerging role of ARHGAP29 in melanoma cell phenotype switching.PMID 40906537Read ↗

TRIM9 switches the morphological phenotype of melanoma cellsSemantic proximity Read ↗

Targeting invasive properties of melanoma cells.Semantic proximity Read ↗

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy ResistanceSemantic proximity Read ↗

Recurrent inactivating RASA2 mutations in melanoma.Semantic proximity Read ↗

RAS pathway regulation in melanoma.Semantic proximity Read ↗

LncRNAs in melanoma phenotypic plasticity: emerging targets for promising therapies.Semantic proximity Read ↗

Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance.Semantic proximity Read ↗

SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma.Semantic proximity Read ↗

The epigenetic regulator TRIM24 controls melanoma cell dedifferentiation and resistance to treatment in melanomaSemantic proximity Read ↗

Single-cell gene regulatory network analysis reveals new melanoma cell states and transition trajectories during phenotype switchingSemantic proximity Read ↗

hMAGEA2 Promotes Cell Growth and Tumorigenicity in MelanomaSemantic proximity Read ↗

Rhpn2 promotes zebrafish melanoma development and aggressiveness <i>in vivo</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.