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The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell Invasion

20 Jul 2012

Abstract excerpt

During progression of melanoma, malignant melanocytes can be reprogrammed into mesenchymal-like cells through a process similar to epithelial-mesenchymal transition (EMT), which is associated with downregulation of the junctional protein E-cadherin and acquisition of a migratory phenotype. Recent evidence supports a role for SLUG, a transcriptional repressor of E-cadherin, as a melanocyte lineage transcription...

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PMID: 22911700
DOI: 10.1371/journal.pone.0040378

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Related research

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Research trail→

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The Epithelial-Mesenchymal Transition (EMT) Regulatory Factor SLUG (SNAI2) Is a Downstream Target of SPARC and AKT in Promoting Melanoma Cell InvasionPMID 22911700Read ↗

SPARC Represses E-Cadherin and Induces Mesenchymal Transition during Melanoma DevelopmentSemantic proximity Read ↗

Transcriptional activation of ZEB1 by Slug leads to cooperative regulation of the epithelial-mesenchymal transition-like phenotype in melanoma.Semantic proximity Read ↗

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory FunctionSemantic proximity Read ↗

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesisSemantic proximity Read ↗

WNT1 Inducible Signaling Pathway Protein 1 (WISP1) stimulates melanoma cell invasion and metastasis by promoting epithelial – mesenchymal transitionSemantic proximity Read ↗

Role of the epithelial-mesenchymal transition regulator Slug in primary human cancersSemantic proximity Read ↗

Osteopontin (OPN/SPP1), a Mediator of Tumor Progression, Is Regulated by the Mesenchymal Transcription Factor Slug/SNAI2 in Colorectal Cancer (CRC)Semantic proximity Read ↗

SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma.Semantic proximity Read ↗

Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cellsSemantic proximity Read ↗

UTRN inhibits melanoma growth by suppressing p38 and JNK/c-Jun signaling pathwaysSemantic proximity Read ↗

STAM-binding protein regulates melanoma metastasis through SLUG stabilizationSemantic proximity Read ↗

SPARC: a matricellular regulator of tumorigenesisSemantic proximity Read ↗

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