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Article

SPARC: a matricellular regulator of tumorigenesis

6 Oct 2009

Abstract excerpt

Although many clinical studies have found a correlation of SPARC expression with malignant progression and patient survival, the mechanisms for SPARC function in tumorigenesis and metastasis remain elusive. The activity of SPARC is context- and cell-type-dependent, which is highlighted by the fact that SPARC has shown seemingly contradictory effects on tumor progression in both clinical correlative studies and in...

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PMID: 19809893
DOI: 10.1007/s12079-009-0072-4

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