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Article

CD34(+) fibrocytes in melanocytic nevi and malignant melanomas of the skin.

Virchows Archiv : an international journal of pathology - 1 Nov 2008

Wessel Cordula, Westhoff Christina C, Nowak Katharina, Moll Ingrid, Barth Peter J

Abstract excerpt

CD34(+) fibrocytes are constitutive elements of the human connective tissue. The stroma associated with invasive carcinomas is characterized by a stereotypic loss of CD34(+) fibrocytes and a phenotype change towards CD34(-) alpha-Smooth muscle actin (SMA)(+) myofibroblasts. Secreted protein acidic and rich in cysteine (SPARC) is an important mediator of tumor-associated stromal remodeling. Melanocytic lesions of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18813945
DOI: 10.1007/s00428-008-0667-9

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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