Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A prototypic matricellular protein in the tumor microenvironment—Where there's SPARC, there's fire

5 Feb 2008

Abstract excerpt

Within the tumor microenvironment is a dynamic exchange between cancer cells and their surrounding stroma. This complex biologic system requires carefully designed models to understand the role of its stromal components in carcinogenesis, tumor progression, invasion, and metastasis. Secreted protein acidic and rich in cysteine (SPARC) is a prototypic matricellular protein at the center of this exchange. Two...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Dental Protein Studies
Share to Cancer Research and Treatments
Share to Digestive system and related health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18253934
DOI: 10.1002/jcb.21688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A prototypic matricellular protein in the tumor microenvironment—Where there's SPARC, there's firePMID 18253934Read ↗

SPARC: a matricellular regulator of tumorigenesisSemantic proximity Read ↗

SPARC, a matricellular protein that protects cancer from therapySemantic proximity Read ↗

Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesisSemantic proximity Read ↗

Integrative genomic analyses of secreted protein acidic and rich in cysteine and its role in cancer prediction.Semantic proximity Read ↗

Matricellular Proteins: A Sticky Affair with CancersSemantic proximity Read ↗

The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteineSemantic proximity Read ↗

Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and ProgressionSemantic proximity Read ↗

The extracellular matrix: A dynamic niche in cancer progressionSemantic proximity Read ↗

Associations of tumor suppressor SPARCL1 with cancer progression and prognosisSemantic proximity Read ↗

Omics Overview of the SPARC Gene in MesotheliomaSemantic proximity Read ↗

SPARCL1 Is a Novel Prognostic Biomarker and Correlates with Tumor Microenvironment in Colorectal CancerSemantic proximity Read ↗

Modulating secreted components of tumor microenvironment: A masterstroke in tumor therapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.