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Article

NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse

15 Nov 2007

Abstract excerpt

Post-translational phosphorylation of proteins provides a mechanism for cells to switch on or off many diverse processes, including responses to replication stress. Replication-stress-induced phosphorylation enables the rapid activation of numerous proteins involved in DNA replication, DNA repair and cell cycle checkpoints, including replication protein A (RPA). Here, we report that hydroxyurea (HU)-induced RPA...

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PMID: 18003706
DOI: 10.1242/jcs.004580

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