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Article

Monoallelic amplification of estrogen receptor-alpha expression in breast cancer.

Cancer research - 15 May 2000

Schuur E R, Weigel R J

Abstract excerpt

Gene amplification and loss of heterozygosity are alterations to chromosomal structure whereby tumor cells alter patterns of gene expression. We have identified a novel mechanism of gene regulation in which cancer cells predominantly express one of the two alleles of a gene. Estrogen receptor (ER)-alpha is overexpressed in hormone-responsive breast cancer compared with normal breast epithelial cells. Using a...

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Share to Breast Neoplasms
Share to Electrophoresis, Polyacrylamide Gel
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Receptors, Estrogen

Share to Transcription, Genetic

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PMID: 10825128

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MAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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