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Transcriptional Control of the <i>ERBB2</i> Amplicon by ERRα and PGC-1β Promotes Mammary Gland Tumorigenesis

20 Oct 2010

Abstract excerpt

Overexpression of ERBB2 and its neighboring genes on chromosome 17 occurs in approximately 25% of breast tumors and is associated with poor prognosis. While amplification of the 17q12-21 chromosomal region often correlates with an increase in the transcriptional rates of the locus, the molecular mechanisms and the factors involved in the coordinated expression of genes residing within the ERBB2 amplicon remain...

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PMID: 20961995
DOI: 10.1158/0008-5472.can-10-2840

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Transcriptional Control of the <i>ERBB2</i> Amplicon by ERRα and PGC-1β Promotes Mammary Gland TumorigenesisPMID 20961995Read ↗

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