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Article

ERBB4 promoter polymorphism is associated with poor distant disease-free survival in high-risk early breast cancer.

PloS one - 1 Jan 2014

Kurppa Kari J, Rokavec Matjaz, Sundvall Maria, Kellokumpu-Lehtinen Pirkko-Liisa, Joensuu Heikki, Brauch Hiltrud, Elenius Klaus

Abstract excerpt

A number of genetic variants have been linked to increased risk of breast cancer. Little is, however, known about the prognostic significance of hereditary factors. Here, we investigated the frequency and prognostic significance of two ERBB4 promoter region variants, -782G>T (rs62626348) and -815A>T (rs62626347), in a cohort of 1010 breast cancer patients. The frequency of nine previously described somatic ERBB4...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Breast Neoplasms
Share to Disease-Free Survival
Share to Gene Expression Regulation, Neoplastic
Share to Genetic Predisposition to Disease
Share to Polymorphism, Single Nucleotide
Share to Promoter Regions, Genetic
Share to Protein Structure, Tertiary
Share to Receptor, ErbB-4

Source

Open in PubMed Open full text

Identifiers

PMID: 25036186
DOI: 10.1371/journal.pone.0102388
PMCID: PMC4103820

Genes

ERBB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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