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Article

RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genes.

Genes, chromosomes & cancer - 1 Aug 2006

Kao Jessica, Pollack Jonathan R

Abstract excerpt

DNA amplification is a frequent occurrence in cancer genomes. While tumor amplicons may harbor known oncogenes "driving" amplification, amplicons rarely comprise only single genes. The potential functional contribution of coamplified genes remains largely unexplored. In breast cancer, 20-30% of tumors exhibit amplification within chromosome band 17q12, containing the ERBB2 oncogene. Analysis of array-based...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16708353
DOI: 10.1002/gcc.20339

Genes

ERBB2
GRB7
STARD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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