Debrisoquine polymorphism: novel CYP2D6 gene Bam HI restriction fragment length polymorphism in the Ngawbé Guaymí Indian of Panama.

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Article

Debrisoquine polymorphism: novel CYP2D6 gene Bam HI restriction fragment length polymorphism in the Ngawbé Guaymí Indian of Panama.

Pharmacogenetics - 1 Dec 1991

Petersen D D, Kong A N, Jorge L F, Nebert D W, Arias T D

Abstract excerpt

Markedly decreased cytochrome P450-mediated metabolism of debrisoquine, sparteine, and more than two dozen additional commonly prescribed drugs is an autosomal recessive trait that has been associated with several RFLP patterns involving the CYP2D6 gene. In Caucasians there are at least six varia...

Topics

Alleles
Biological Evolution
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Humans
Indians, Central American
Male
Mixed Function Oxygenases
Panama
Pedigree
Phenotype
Polymorphism, Restriction Fragment Length
Pseudogenes
Sparteine

Source

Open in PubMed

Identifiers

PMID: 1688244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1688244-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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