Article
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.
Pharmacogenetics - 1 Jun 1995
Dahl M L, Yue Q Y, Roh H K, Johansson I, Säwe J, Sjöqvist F, Bertilsson L
Abstract excerpt
The CYP2D6 genotype and the debrisoquine and mephenytoin hydroxylation phenotypes were studied in 63 Oriental subjects including 21 Chinese, 21 Japanese and 21 Koreans. All subjects were extensive metabolizers of debrisoquine. The incidence of the S-mephenytoin poor metabolizer phenotype was 14% in the Chinese, 24% in the Japanese and 24% in the Korean population, respectively, which is similar to previous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.