Article
Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.
Pharmacogenetics - 1 Jun 1995
Dahl M L, Yue Q Y, Roh H K, Johansson I, Säwe J, Sjöqvist F, Bertilsson L
Abstract excerpt
The CYP2D6 genotype and the debrisoquine and mephenytoin hydroxylation phenotypes were studied in 63 Oriental subjects including 21 Chinese, 21 Japanese and 21 Koreans. All subjects were extensive metabolizers of debrisoquine. The incidence of the S-mephenytoin poor metabolizer phenotype was 14%...
Topics
- Adult
- Alleles
- China
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Female
- Genotype
- Humans
- Hydroxylation
- Japan
- Korea
- Male
- Middle Aged
- Mixed Function Oxygenases
- Pilot Projects
- Sweden