Identification of a novel CYP2D6 allele associated with poor metabolism of sparteine in a Japanese population.

doi:10.1097/00008571-199112000-00006

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Identification of a novel CYP2D6 allele associated with poor metabolism of sparteine in a Japanese population.

Pharmacogenetics - 1 Dec 1991

Kondo I, Yonaha M, Okano K, Gonzalez F J, Kanazawa I

Abstract excerpt

The relationship between genotypes associated with restriction fragment length polymorphisms at the P450 CYP2D locus and the metabolic phenotypes for sparteine in healthy Japanese subjects was investigated. Four distinct restriction fragments of 44 kb, 29 kb, 11.5 kb or 16 + 9 kb after digestion with Xba I were observed. The genotype of Xba I 11.5 kb, which is predictive of the poor metabolizer phenotype in...

Topics

Adolescent
Adult
Aged
Alleles
Asian People
Child
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Male

Middle Aged

Mixed Function Oxygenases

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1688247
DOI: 10.1097/00008571-199112000-00006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1688247-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a novel CYP2D6 allele associated with poor metabolism of sparteine in a Japanese population.PMID 1688247Read ↗

CYP2D6 extensive, intermediate, and poor phenotypes and genotypes in a Polish population.Semantic proximity Read ↗

A new CYP2D6 allele with a nine base insertion in exon 9 in a Japanese population associated with poor metabolizer phenotype.Semantic proximity Read ↗

Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European population.Semantic proximity Read ↗

Genetic polymorphism of CYP2D6 in the Japanese population.Semantic proximity Read ↗

Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism.Semantic proximity Read ↗

Debrisoquine hydroxylase and Parkinson's disease.Semantic proximity Read ↗

Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.Semantic proximity Read ↗

Debrisoquine polymorphism: novel CYP2D6 gene Bam HI restriction fragment length polymorphism in the Ngawbé Guaymí Indian of Panama.Semantic proximity Read ↗

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects.Semantic proximity Read ↗

Evolutionary pharmacogenetics of CYP2D6 in Ngawbe Guaymi of Panama: allele-specific PCR detection of the CYP2D6B allele and RFLP analysis.Semantic proximity Read ↗

CYP2D6 genotype determination in the Danish population.Semantic proximity Read ↗

An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.