Article
Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage.
Molecular and cellular biology - 1 Aug 2006
Mourali Jaouhar, Bénard Alan, Lourenço Filipe Calheiros, Monnet Céline, Greenland Catherine, Moog-Lutz Christel, Racaud-Sultan Claire, Gonzalez-Dunia Daniel, Vigny Marc, Mehlen Patrick, Delsol Georges, Allouche Michèle
Abstract excerpt
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, initially discovered as part of the NPM-ALK fusion protein, resulting from the t(2;5) translocation that is frequently associated with anaplastic large-cell lymphomas. The native ALK protein is normally expressed in the developing and, at a weaker level, adult nervous system. We recently demonstrated that the oncogenic, constitutively...
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